Study on ability of Maxillo-facial growth in the patients with congenital anomalies by HLA-typing

对日本唇裂伴或不伴腭裂(CL/P)患者进行了人类白细胞抗原-B、-DRB1和-DPB1等位基因的核苷酸水平分型。B等位基因B*1501和B*5101与CL/P呈显著正相关，B*1501在女性患者中显著增加(OR=3.6，PC=0.005)，而B*5101在男性患者中明显增加(OR=3.7PC&lt；0.002)。等位基因HLADRB1*0802在CL/P患者中也有增加。相反，患者组未发现HLAB*4403End DRB1*1302(PC=0.004和PC=0.007)。未发现与CL/P显著相关的HLA-DPB1等位基因。因此，本研究提示，HL-DPB1等位基因或紧密连锁的基因座可能参与CL/P的发病。

Nucleotide sequence level typing of HLA-B, -DRB1, and -DPB1 alleles was performed on Japanese patients with cleft lip with or without cleft palate (CL/P). Two HLA-B alleles, B*1501 and B*5101, showed a significant positive association with CL/P. The increase of B*1501 was evident in female patients (OR = 3.6, pc = 0.005), whereas the increase of B*5101 was evident in male patients (OR = 3.7, pc < 0.002). One HLA-DRB1 allele, HLA-DRB1*0802 also showed an increase in CL/P patients. Conversely, HLA-B*4403 End DRBl*1302 were not observed in the patient group (pc = 0.004 and pc = 0.007, respectively). No HLA-DPB1 alleles showed significant association with CL/P. Thus, the present study indicates that HLA alleles, or closely linked loci, may be involved in the pathogenesis of CL/P.