Development of antimicrobial tissue conditioners without ethvl alcohol based on sebacate ester

本研究旨在开发一种以癸二酸酯为基础的无醇抗菌组织调理剂。在本研究中，本研究主要包括以下几个方面：1）组织调理剂和弹性义齿衬垫动态粘弹性能评价方法的建立; 2）商业组织调理剂凝胶化过程中的动态粘弹性能; 3）商业组织调理剂凝胶化后的动态粘弹性能; 4）乙醇对组织调理剂凝胶化过程中和凝胶化后粘弹性能的影响; 5）组织调理剂凝胶化后的动态粘弹性能。组织调理剂的尺寸稳定性与重量变化的关系; 6）义齿衬垫的粘弹性与咀嚼功能的关系; 7）聚乙烯基组织调理剂的咀嚼时间（甲基丙烯酸丁酯）或类似物。我们的结论是，可以通过使用聚（甲基丙烯酸丁酯）或类似物来开发基于癸二酸酯的不含乙醇的抗微生物组织调理剂。我们将进行关于不含乙醇的组织调理剂的耐久性的实验。

The purpose of this research is to development of antimicrobial tissue conditioner without alcohol based on sebacate ester. In this study, we examined as follows.1) Establishment of evaluation method of dynamic viscoelastic properties of tissue conditioners and resilient denture liners.2) Dynamic viscoelastic properties of commercial tissue conditioners during gelation.3) Dynamic viscoelastic properties of commercial tissue conditioners after gelation.4) Influence of ethyl alcohol on viscoelastic properties of tissue conditioners during and after gelation.5) Relationship between dimensional stability and weight changes of tissue conditioners.6) Relationship between viscoelastic properties of denture liners and masticatory function.7) Gelation time of tissue conditioners base on poly (butyl methacrylate) or similar.As stated above, we concluded that it is possible to develop the antimicrobial tissue conditioners without ethyl alcohol based on sebacate ester by using poly (butyl methacrylate) or similar. We will conduct experiment concerning the durability of the tissue conditioners without ethyl alcohol.