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Research on Molecular Target therapy for Acral Melanoma

Research on Molecular Target therapy for Acral Melanoma
肢端黑色素瘤分子靶向治疗研究
批准号:
20591318
负责人:
MURATA Hiroshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
To personalize the therapy with molecular targeting therapy for melanoma, we showed that : 1. two of 28 case had activating mutation of KIT gene and one of these mutation, D820Y, was sensitive to the sunitinib. 2. Circulating melanoma cells could extract by using anti-HMW-MAA antibody and we detect the BRAF mutation states from them. 3. We showed polyclonality of melanoma cells on BRAF mutation states.
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DOI: 10.1111/j.1755-148x.2009.00645.x
发表时间: 2010-02
期刊: Pigment Cell & Melanoma Research
影响因子: 4.3
作者: [M. Takata;H. Murata;T. Saida]
通讯作者: M. Takata;H. Murata;T. Saida
Pathological activation of KIT is common in acral and mucosal melanomas.
KIT 的病理激活常见于肢端和粘膜黑色素瘤。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Ashida A, Takata M, Murata H, Kido K, Saida T.]
通讯作者: Saida T.
Pathological activation of KIT in acral and mucosal melanomas.
KIT 在肢端和粘膜黑色素瘤中的病理激活。
DOI: --
发表时间: 2009
期刊: Int J Cancer 124
影响因子: --
作者: [Ashida A, Takata M, Murata H, Kido K, Saida T]
通讯作者: Saida T
NADPH oxidase (Nox) 4 contribute to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression.
NADPH 氧化酶 (Nox) 4 通过调节 G2-M 细胞周期进程促进黑色素瘤细胞的转化表型。
DOI: --
发表时间: 2009
期刊: Cancer Res 69
影响因子: --
作者: [Yamaura M, Mitsushita J, Furuta S, Kiniwa Y, Ashida A, Goto Y, Shang WH, Kubodera M, Kato M, Takata M, Saida T, Kamata T]
通讯作者: Kamata T
14
    Development of dynamic-impression type light-cured soft denture liners with photocatalyst function and healing acceleration function
    • 批准号:
      17H04393
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.98万
    • 财政年份:
      2017
    • 负责人:
      MURATA Hiroshi
    • 依托单位:
    Development of mouth moisturizer with functions of acceleration of salivary secretion and activation of mucosa for denture patients with dry mouth
    • 批准号:
      16K15806
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.16万
    • 财政年份:
      2016
    • 负责人:
      MURATA Hiroshi
    • 依托单位:
    Development of a multi-function soft denture liner having bFGF-controlled release and self-cleaning functions
    • 批准号:
      26293413
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.57万
    • 财政年份:
      2014
    • 负责人:
      MURATA Hiroshi
    • 依托单位:
    Investigation of visual field employing Bayes and machine learning method
    • 批准号:
      25861618
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.41万
    • 财政年份:
      2013
    • 负责人:
      MURATA Hiroshi
    • 依托单位:
    海外基金