Analysis of Immnological Response in the Stomach of Suncus murinus against Newly Isolated Helicgbacter Species.

在1998年，我们从我们设施中饲养的所有臭鼩（SUN系）的胃中分离出新的螺杆菌物种，并且分离物与动物中慢性胃炎的组织学病变的存在相关（Curr Microbiol 37：44-51，1998）。本研究分析了梭子鱼胃对幽门螺杆菌（Helicobacter suncus JM 1459）的免疫反应，结果表明，自然感染和实验感染的梭子鱼胃均出现了幽门螺杆菌（Helicobacter suncus JM 1459）。孙库斯。胃炎由单核细胞组成，但未观察到嗜中性粒细胞。从感染H.结果表明，单核细胞在海蛞蝓胃内抗幽门螺杆菌的免疫应答中起重要作用，并从本研究构建的cDNA文库中获得了海蛞蝓胃炎相关基因。澄清细节的免疫反应，在胃中的臭鼬需要分析的克隆。

In 1998, we isolated novel Helicobacter species from the stomach of all Suncus murinus (SUN line) maintained in our facility, and the isolates correlated with the presence of histologic lesions of chronic gastritis in the animals (Curr Microbiol 37 : 44-51, 1998). In this study, immunological response in the stomach of Suncus murinus to the Helicobacter species (Helicobacter suncus JM1459) was analysed.Gastritis was observed in stomachs of all Suncus murinus naturally and/or experimentally infected with H. suncus. The gastritis consisted of mononuclear cells but neutrophilia was not observed. Ten clones from the eDNA library constructed from stomachs with gastritis of Suncus murinus infected with H. suncus" were strongly expressed in stomachs with gastritis but not in stomachs without gastritis.Our results suggested that mononuclear cells play an important role in the host immune response in stomachs of Suncus murinus against Helicobacter species, and the gastritis related gene was obtained from the cDNA library constructed in this study. Clarification of details of immunological response in the stomachs of Suncus murinus requires analysis of the clones.