Studies on physiological characteristics of an inbred rat with resistance adaptation to heat and searches for related-genes

本研究对具有耐热适应基因型的近交FOK大鼠进行了研究，并寻找了耐热适应相关基因。此外，脑损伤的对照品系大鼠 * 灌注手术摘除的唾液腺。实验结果表明，蒸发冷却受中枢神经系统负反馈控制。FOK大鼠表现出有趣的反应，其他压力比热。FOK大鼠对心理应激和脂多糖的反应主要是高热。我们以前报道过FOK大鼠具有耐寒性。在本研究中，一种激素在冷暴露的FOK大鼠中大量增加。利用cDNA微阵列技术寻找FOK大鼠下丘脑中先天性表达的基因。FOK大鼠下丘脑中高度表达的三个基因。这些发现被认为是有益的健康护理在强烈的压力条件下，在各种情况下。

We studied the characteristics of the inbred FOK rat with genotypic resistance adaptation to heat and related-genes were searched. In addition, brain injury in control strain of rats *erfusion of surgically extirpated salivary glands. The evidence suggested that evaporative cooling was regulated with mode of negative feedback control by central nervous system. FOK rats showed interesting responses to other stresses than heat. FOK rats largely responded to psychological stress and lipopolysaccharide with large fever. We previously reported that FOK rats were cold resistant. In the present study, a hormone largely increased in cold-exposed FOK rats. Genes which are congenitally expressed in the hypothalamus of FOK rats were searched using cDNA MicroArray analysis. Three genes thought to be highly expressed in the hypothalamus of FOK rats. These findings thought to be beneficial for health care in strongly stressed condition in various situations.