A historical cohort on the risk of death from cancer in forestry workers possibly exposed to dioxin from spraying weeds

这项研究旨在通过跟踪一组可能接触过二恶英的国家林业工人，澄清二恶英对健康的影响，特别是死于癌症的风险程度。从几个名单中确定的2266名国家林业工人中，有2091名工人的地址也被列为该队列的成员。这些工人是死是活已查明。在死亡案件中，获得了司法部的许可，可以审查死亡证明或死亡登记证。根据国际疾病分类（ICD）确定主要死亡原因后，在95%置信区间内根据标准化死亡率（SMR）估计是否存在过量死亡。在喷洒含有2,4,5 - T除草剂的966名男性工人中，有224名工人在1978年（开始追踪时）至1998年期间死亡。对这些男性工人总死亡人数的分析得出的SMR为0.69(95%可信区间：0.6 1 -0.79)，显著低于全国平均水平。心脏病死亡为0.58(0.39-0.85)，脑血管意外死亡为0.58(0.37-0.85)，两者的SMR均显著低于1。在192名女性林业工人中，有16人死亡。该组总死亡的SMR为0.43(0.26-0.69)，明显低于全国平均水平。虽然置信区间较大，但由于很少有受试者死于心脏病或脑血管意外，所以点估计值小于1。这些结果包括苗田64名工人的结果，与男性工人的结果相同。人们认为，这些结果表明了健康工人的影响。所有恶性肿瘤致死原因男性林业工人的SMR为0.70(0.56 ~ 0.86)，女性林业工人的SMR为0.78(0.41 ~ 1.42)，种田女工的SMR为1.42（0.67 ~ 2.9）。这些数值低于全国平均水平。在两性中均未观察到部位特异性癌症的死亡率显著增加。在分析的时间段内，所有受试者的死亡率保持在20%左右。因此，我们认为有必要对受试者进行更长时间的跟踪研究，以获得明确的结论。少

This study aimed to clarify the influence of dioxin on health, particularly the degree of risk of death from cancer, by tracking a group of national forestry workers who may have been exposed to dioxin.Of 2266 national forestry workers identified from several name lists, 2091 workers whose addresses were also available were listed as members of the cohort. It was ascertained whether these workers were alive or dead. In the cases of death, permission from the Ministry of Justice was obtained to examine the death certificate or death registration certificate. After determining the primary cause of death according to the International Classification of Diseases (ICD), estimation of whether or not there were excessive deaths was made based on the Standardized Mortality Ratio (SMR) at the 95% confidence interval.Of the 966 male workers assumed to have been exposed by spraying a weed killer containing 2, 4, 5 - T, 224 workers had died in the period from 1978 (when tracking was started) to 20 … More 02. Analysis of the total deaths of these male workers produced an SMR of 0.69 (95% confidence interval: 0.6 1 -0.79), which was significantly lower than the national average. Death due to cardiac disease was 0.58 (0.39-0.85), and death due to cerebral vascular accident was 0.58 (0.37-0.85), with the SMR being significantly lower than 1 in both cases. Of the 192 female forestry workers, 16 had died. The SMR of total deaths in this group was 0.43 (0.26-0.69), which was significantly lower than the national average. Although the confidence interval was large, because few subjects died from cardiac disease or cerebral vascular accident, the point estimation value was less than 1. These results include those for 64 workers in seedling fields, which were the same as the results for the male workers. It was thought that these results suggested an effect of healthy workers.The SMR for all malignant tumors as the cause of death for male forestry workers was 0.70 (0.56-0.86), for female forestry workers it was 0.78 (0.41-1.42) and for female workers in the seedling fields it was 1.42 (0.67-2.9 1 ). These values are lower than the national average. No significantly increased deaths of site-specific cancers were observed in both sexes.The death rate for all subjects in the time period analyzed remained at around 20%. Therefore, we believe that it is necessary to follow the subjects for a longer period in order to obtain a definite conclusion. Less