Studies on the effects of heat shock proteins of the HSP110 family on the aggregation of poly-glutamine

1. 我们在体外研究了HSP110家族成员HSP110、APG-1和APG-2对聚谷氨酰胺聚集的影响。虽然HSP70抑制了聚谷氨酰胺的聚集，但对这些分子没有抑制作用。我们在体外研究了HSP110、APG-1和APG-2对聚谷氨酰胺诱导的细胞凋亡的影响。HSP70虽能抑制细胞凋亡，但对这些分子无抑制作用。我们观察到缺乏atp酶结构域的HSP70对聚谷氨酰胺具有抗聚集作用，但不具有抗凋亡作用。

1. We have studied the effects of HSP110, APG-1 or APG-2, which are belonging to the HSP110 family, on the aggregation of poly-glutamine in vitro. Although HSP70 inhibited the aggregation of poly-glutamine, these molecules did not inhibited.2. We have studied the effects of HSP110, APG-1 or APG-2 on the Poly-glutamine induced apoptosis in vitro. Although HSP70 inhibited the apoptosis, these molecules did not inhibited.3. We have observed that HSP70 whith lacks its ATPase domain showed the anti-aggregation effect on polu-glutamine but not the anti-apoptotic effect.