Risk assessment of cancer risk based on life-style and genetic diagnosis -Aiming at the behavioral of life style.

我们研究了药物代谢酶（细胞色素P450、谷胱甘肽S-转移酶（GST）、苯酚硫酸化苯酚磺基转移酶（SAT）、N-乙酰转移酶（NAT））和维生素D受体（VDR）对不同个体的影响。结果如下：1）采用病例对照研究方法，探讨7个基因的遗传多态性、吸烟与胃癌、前列腺癌和尿路上皮癌的关系。因此，我们发现CYP 2A 6缺失与胃腺癌相关。然而，CYP 2A 6和CYP 2 E1的基因多态性与尿路上皮癌的风险无关。NAT 2和ST 1A 3基因多态性是尿路上皮癌发生的遗传因素。CYP 1A 1基因多态性及其与GSTM 1的联合可能与前列腺癌易感性相关。另外，在研究VDR基因多态性与前列腺癌和肾癌的关系时，发现两者之间存在显著的相关性。为了研究癌症与吸烟量之间的关系，我们将研究组按NAT 2基因型划分。分析吸烟量与尿路上皮癌发生的关系。在NAT 2基因型中观察到不同的优势比模式，并证实存在对环境化学暴露敏感性不同的群体。2）酒精相关癌症的遗传易感性标志物可以个性化吸烟的危害并激励戒烟。我们选择了一个使用这种干预研究的工作场所。分别有五十六%的工人同意酒精相关癌基因的遗传反馈。

We studied the influence on differing individuals of drug metabolic enzymes (Cytochrome P450, Glutathione S-transferase (GST), phenol-sulfating phenol sulfotransferase (SAT), N-acetyltransferase (NAT)), and vitamin D receptor (VDR). Following are the results : 1) cancer-causing relevance ; 2) assessment of intervention study that feedback of genetic susceptibility to behavioral change.1) A case control study was carried out to examine the relationship between the genetic polymorphisms of seven genes, cigarette smoking and gastric, urothelial and prostate cancer. As a result, we found that the CYP2A6 deletion was associated with gastric adenocarcinoma. However, genetic polymorphisms of CYP2A6 and CYP2E1 were not associated with risk of urothelial cancer. NAT2 and ST1A3 genetic polymorphisms are heredity factors in the occurrence of urothelial cancer. CYP1A1 polymorphism and its combinations with GSTM1 may be associated with prostate cancer susceptibility. In addition, while investigating the relationship between prostate and renal cancer with VDR genetic polymorphism, we found that there were significant relationships between them respectively. To investigate the relationship between cancer and the quantity of smoking, we divided the research group by a genotype of NAT2. Then we analyzed the quantity of smoking and its relationship to urothelial carcinogenesis. Different patterns of odds ratio were observed in a genotype of NAT2, and the existence of a group that was different in sensitivity to environmental chemical exposure was suggested.2) Markers of genetic susceptibility to alcohol -related cancer could personalize harms of smoking and motivate cessation. We selected a workplace that used this intervention study. Fifty-Six percent of workers agreed to genetic feedback of alcohol related cancer gene respectively.