Multi-center epidemiologic study on dietary and urinary selenium and blood pressure

本研究旨在调查日本4个成年人群膳食硒摄入量、血清硒浓度和尿硒排泄量与血压的关系。本研究是在4个国家进行的营养素与血压的国际合作研究INTERMAP的一部分，从富山、和歌山、北海道的3个工作场所和滋贺的1个町的4个人群中，各随机抽取约300名40-59岁的男女。共1，145名参与者（574名男性和571名女性）使用随机零点血压计通过高度标准化方法测量血压，使用24小时回忆法进行4次饮食调查，并进行2次24小时尿液收集。膳食硒摄入量使用INTERMAP日本食物表计算。测定尿硒浓度，计算24小时尿硒排泄量。血清硒浓度测定结果显示，男性平均膳食硒摄入量为191微克/日，女性为151微克/日。50岁组摄入量高于40岁组。硒的摄入密度约为85微克/1000千卡，男女之间相似。据估计，男性24小时尿硒排泄量平均为139 mcg，女性为116 mcg，其中73-77%的饮食摄入量估计通过尿液排泄。在多元回归分析中，调整可能的混杂因素后，血压与男性和女性的尿硒排泄量或膳食硒摄入密度均无显著相关性。

This study is to investigate the relationship of dietary intake, serum concentration and urinary excretion of selenium to blood pressure in 4 adult Japanese populations. The study was conducted as a part of the INTERMAP, an international cooperative study on nutrients and blood pressure among four countries.About 300 men and women aged 40-59 were randomly selected from each of 4 populations ; 3 worksites in Toyama, Wakayama, Hokkaido, and one town in Shiga. A total of 1,145 participants (574 men and 571 women) were measured their blood pressure by highly standardized method using random zero sphygmomanometer, had 4 dietary survey using 24 hour recall method, and had 2 set of 24 hour urinary collection. Dietary selenium intake was calculated using INTERMAP Japan food tables. Urinary selenium concentration was measured, and 24 hour urinary excretion of selenium was calculated. Serum selenium concentration was measured in subsamples.Mean dietary selenium intake was estimated to be 191mcg/day in men and 151mcg/day in women. The intake was more in subjects aged 50's than in those aged 40's. Intake density of selenium was approximately 85mcg/1000kcal, which was similar between men and women. Mean 24 hour urinary excretion of selenium was estimated to be 139mcg in men and 116mcg in women, where 73-77% of dietary intake was estimated to be excreted in urine. Serum selenium concentration was not correlated significantly with urinary excretion or dietary intake of selenium.In multiple regression analyses, blood pressure was not significantly related with urinary selenium excretion or dietary selenium intake density both in men and in women, after adjustment for possible confounders.