Effects of Food Restriction during Pregnancy and Lactation on the Health of Maternal Body and Progeny

本文研究了大鼠孕期和哺乳期能量限制对母体和子代生长发育的影响。对照组为添加20%酪蛋白和L-蛋氨酸的日粮。限制组大鼠在妊娠期和哺乳期分别给予能量限制率为15%（R15）、30%（R30）和50%（R50）的酪蛋白饲料。在R30和R50组的新生幼仔中观察到生长迟缓。出生后3周，所有限制组的子代均出现生长迟缓。观察到能量限制率越高，子代生长迟缓越严重。出生后5周，R50组仔鼠出现生长迟缓，研究了孕期和哺乳期不同蛋白质和食物限制对母鼠体和仔鼠生长的影响。自由采食组饲喂20%酪蛋白饲料（C）或20%大豆分离蛋白饲料（S）。限制组大鼠在妊娠期和哺乳期分别以自由采食量的-30%的比例饲喂酪蛋白饲料（CR）或大豆蛋白饲料（SR）。与S组相比，SR组新生仔鼠生长发育迟缓。在出生后3周，与自由采食组相比，限制组的后代中观察到生长迟缓，与酪蛋白组相比，SPI组的后代中观察到生长迟缓。妊娠期限食对母体和子代的生长发育影响不大，但妊娠期和哺乳期限食对母体和子代的生长发育影响显著。在哺乳期，母体饮食中的蛋白质质量非常重要，即使在自由采食组中也是如此。

Influence of energy restriction in rats during pregnancy and lactation on the maternal body and the growth of progeny were studied. The control was a 20% casein diet supplemented with L-methionine. Rats of restricted groups were given casein diet at energy restriction rate of either 15% (R15), 30% (R30) or 50% (R50) during pregnancy and lactation. Retardation of growth was observed in newborn pups of R30 and R50 groups. At 3weeks after birth, the retardation of growth was observed in the progeny of all restricted groups. It was observed that the higher the rate of energy restriction, the more severe the growth retardation of progeny. At 5 weeks after birth, the progeny of R50 groups showed the retardation of growth compared with the other groups.Effects of difference of protein and food restriction during pregnancy and lactation on the rat maternal body and the growth of progeny were studied. Rats of ad libitum groups were fed 20% casein diets (C) or 20% soy protein isolate (SPI) diets (S). Rats of restricted groups were given casein diets (CR) or SPI diets (SR) at rate of minus 30% of ad libitum groups during pregnancy and lactation. Retardation of growth was observed in newborn pups of SR group, compared with S group. At 3 weeks after birth the retardation of growth was observed in the progeny of restricted groups compared with ad libitum groups, and in the progeny of SPI groups, compared with casein groups. We concluded that the food restriction during pregnancy had little effect on the maternal body and the growth of progeny with a high quality protein food but food restriction through pregnancy and lactation affected them remarkably. In the lactation period a quality of protein in the maternal diets was important even in ad libitum groups.