Formulation and Characterization of Monodispersed Microcapsules and Nanocapsules

对微胶囊和纳米胶囊的配方及表征进行了研究，总结如下：以单分散的水包油乳液为原料，采用微通道乳化和溶剂蒸发法制备了相对单分散的脂质微/纳米颗粒。对微通道板进行了放大，微通道乳化能力在原有5ml/h的基础上提高了一个数量级。采用微通道乳化法制备单分散明胶乳液，并用金合欢液凝聚包封制备单分散明胶-金合欢微胶囊。应用计算流体力学方法对直通式微通道的液滴形成过程进行了分析。建立了圆形（10 μm）和长方形（10 μm和40 μm）多孔微通道的CFD模型，仿真结果与实验结果吻合较好。研制了一种新型非对称直通式微通道器件；两层狭缝和微孔结构，比传统的对称直通式微通道具有更高的液滴生产率。采用高压均质机对蛋白基乳液进行纳米颗粒的制备，并对功能成分的包封方法进行了研究。

Research on Formulation and characterization of microcapsules and nanocapsules has been carried out, and summarized as follows.1.Lipid micro/nanoparticles with relatively monodisperse were successfully obtained from monodispersed oil-in-water emulsion by microchannel emulsification as well as solvent evaporation method.2.Scale up of microchannel plate was done, and microchannel emulsification capacity was increased one magnitute from former 5ml/h productivity.3.Monodispersed gelatin-acacia microcapsules were prepared by formation of monodispersed gelatin emulsion with the use of microchannel emulsification as well as coacervate encapsulation with the use of acacia solution.4.CFD (Computatinal Fluid Dynamics) was applied to the analysis of droplet formation from straight-through microchannel. CFD model of circular (10 μm) and oblong (10 and 40 μm) shaped though holed microchannel was constructed and the simulation results agreed well with the experimental results.5.New device of asymmetric straight-through microchannel has been developed ; two layers of slit and micro-hole structure, and exhibited higher droplet productivity than conventional symmetric straight-through microchannel.6.Formulation of nanoparticles was carried out by protein-based emulsion with the use of high-pressure homogenizer, and the method of encapsulation of functional component was newly developed.