Development of osteoconductive materials using ion conductive ceramics

基于热刺激去极化的离子传输极化实验表明，离子导电陶瓷表面可以产生大的表面电荷。通过模拟体液实验，我们证明了电极化引起的表面负电荷增加了离子导电陶瓷表面的生长电导率，而正电荷降低了生长能力。离子导电陶瓷的电荷诱导表面在植入后7d促进了犬骨大范围缺损区的骨重建，但这一过程随电荷极性的不同而不同。关于体外过度生长的激活场的概念应该推广到植入骨组织的电极化离子导电陶瓷的体内钙化反应中。此外，我们还证明了电极化技术不仅适用于羟基磷灰石，也适用于氧化锆和生物活性玻璃，建立了离子导电陶瓷的电极化技术。

Large surface charges were demonstrated to be inducible on ionic conductive ceramics by ion transport polarization based on thermally stimulated depolarization measurements. We have been demonstrated by simulated body fluid tests that the negative, surface charges induced by the electrical polarization increased the overgrowth conductivity on the ionic conductive ceramic surface but that the positive charge diminished the overgrowth ability. The charge-induced surfaces of the ionic conductive ceramics promoted bone reconstructions in wide defects of canine bones at 7days after the implantation, whereas the processes varied according to the charge polarity. The idea of the activated field concerning the in vitro overgrowth should be extensible into the in vivo calcification reactions of the electrically polarized ionic conductive ceramics implanted in bone tissues. Moreover, we have proved that the electrical polarization techniques were applicable not only to hydroxyapatite but also to zirconia and bioactive glass and established the electrical polarization technologies for ionic conductive ceramics.