Influence of central nervous system on masticate dysfunction from childhood of SAM mice

为了研究咀嚼功能障碍(管饲)对海马区的影响，用幼年(出生后15周)和老年(出生后35周)Senessence Accelerated小鼠(SAMP1)进行了实验。作为行为学检查，于仔鼠开始喂养后第8天开始进行Morris水迷宫实验。通过Morris‘s水迷宫实验，对与水迷宫实验相关的海马区Fos阳性细胞、海马神经细胞和锥体细胞的数量进行了检测。结果管饲习服后，老年小鼠的空间再认能力下降，海马区Fos阳性细胞、神经元和锥体细胞的数量减少，但幼年小鼠无此变化。这些动物实验结果表明，咀嚼功能障碍(管饲)减少了信息输入到海马区，降低了空间再认能力，加速了衰老进程。

To investigate the influence of masticatory dysfunction(tube feeding) on the hippocampus, it was conducted an experiment using juvenile (15-week-old after birth) and elderly (35-week-old after birth) Senessence accererated mice (SAMP1). As a behavioral investigation, Morris' water maze test was conducted from 8 days after cube feeding were started. As morphological investigations, the numbers of fos-positive cell, which were linked to the water maze test in the hippocampus, neurons cell and pyramidal cell in the hippocampus were measured after Morris' water maze test.As results in elderly mice acclimated by tube feeding, spatial recognition was reduced, and the number of fos-positive cells, neurons cells and pyramidal cells in the hippocampus was decreased, but not in the juvenile mice.The results of these animal experiments suggest that masticatory dysfunction (tube feeding) decreases information input into the hippocampus, reducing spatial recognition and accelerating the process of aging.