Elucidation of the pathophysiology of lifestyle-related disease and new approach for its prevention verification and development of fetal origin hypothesis

我们研究了日本爱知县年龄在35 - 66岁的3053名日本职场人群（2285名男性和768名女性），他们回答了一份自我报告的问卷，包括病史、药物使用、生活方式特征和出生体重。他们接受了体格检查，包括身高、体重和血压，并提供了代谢综合征（MS）的所有组成部分的数据。在出生体重<2,500、2,500-<3,000、3,000-<3,500、3,500-g组中，MS的多因素校正比值比分别为1.45、1.05、1.04和1.00（参考）。总体而言，出生体重<2500g的受试者可能具有较高的MS患病率，但出生体重与MS之间没有显著相关性。为了评估肥胖（BMI >=25kg/m2）的改变对出生体重与MS之间相关性的影响，将本研究的受试者分为BMI 25kg/m2以下和高于25kg/m2两组。仅在体重指数>=25kg/m2的受试者中，MS存在的ORs与出生体重类别呈负线性关系，具有统计学意义。在BMI <25kg/m2的受试者中，出生体重<2500g的受试者也可能有较高的MS患病率，但统计学上不显著。我们比较了在8类出生体重/当前BMI组合中，除肥胖外，4种MS成分中至少有两种的or。当高出生体重（>= 3500 g）和非肥胖（BMI <25kg/m2）受试者时，低出生体重（< 2500 g）和非肥胖受试者的多重调整OR为2.30。肥胖组MS患病率明显高于肥胖组，低出生体重组（< 2500 g）和肥胖组（BMI =25kg/m2）的多因素校正OR最高（5.06,95%可信区间：2.38 ~ 10.8）。

We studied a workplace population of 3,053 Japanese (2,285 men and 768 women) aged 35 to 66 years in Aichi Prefecture, Japan, who responded to a self-reported questionnaire including medical history, medication use, lifestyle characteristics, and birth weight. They underwent a physical examination including height, weight, and blood pressure, and provided the data on all the components of the metabolic syndrome (MS) . Multi-adjusted odds rations of MS are 1.45, 1.05, 1.04, and 1.00 (reference) in birth weight categories of <2,500, 2,500-<3,000, 3,000-<3,500, 3,500-g, respectively. Overall, the subjects with birth weight of <2500g were likely to have a high prevalence of MS, but there was no significant association between birth weight and MS. To assess the effect modification of obesity (BMI >=25kg/m2) on the association between birth weight and MS, the present subjects were classified as either below or above BMI 25kg/m2. The inverse linear trends in the ORs for the presence of MS according to birth-weight category were statistically significant only among subjects with BMI >=25kg/m2. Among subjects with BMI <25kg/m2, the subjects with birth weight of <2500g were also likely to have a high prevalence of MS though statistically not significant We compared ORs for having at least two out of 4 MS components other than obesity among the eight categories of birth-weight/current BMI combinations. When the subjects with high birth weight(>=3,500g)and non-obese(BMI of <25kg/m2), the multi-adjusted OR of subjects with low birth weight (< 2,500g) and non-obese was 2.30. The obese subjects had a significantly higher prevalence of MS and the highest multi-adjusted OR (5.06, 95% confidence interval : 2.38-10.8)was observed among the subjects with low birth weight(<2,500g) and obese (BMI of >=25kg/m2) .