Determinants of serum cholesteryl ester transfer protein(CETP) and its association with coronary artery calcium in Japanese and US men.

胆固醇酯转运蛋白（CETP）与冠心病的关系存在争议。在血清高密度脂蛋白胆固醇（HDL-C）水平较高的人群中，如日本，血液CETP水平及其对冠状动脉粥样硬化的影响可能与美国人群不同。以前没有研究比较CETP及其对日本和美国白人动脉粥样硬化的影响。在2002-2005年，以社区为基础的249名日本人在草津市，滋贺和233名美国白色男子在阿勒格尼县，宾夕法尼亚州，年龄在40至49岁的随机样本进行了检查，冠状动脉钙（CAC）确定的电子束计算机断层扫描和血清CETP浓度。日本的平均CETP浓度显著低于美国（2.24 mg/L（标准差，0.45）vs. 2.43 mg/L（标准差，0.49））。在调整其他心血管危险因素后，日本男性血清CETP与CAC呈正相关（CETP差异为1 mg/L的比值比（OR），OR ; 4.27，95%置信区间（CI）：1.59，11.5）。即使调整了低密度脂蛋白胆固醇和高密度脂蛋白胆固醇，这种关系也没有受到影响。在美国白色男性中，血清CETP与CAC无关（OR，0.79，95% CI：0.40，1.56）。这一发现值得进一步研究。

The relationship between cholesteryl ester transfer protein(CETP) and coronary heart disease is controversial. In populations with a higher serum high-density-lipoprotein cholesterol(HDL-C) level such as in Japan, blood CETP level and its effect on coronary atherosclerosis may be different from those of US populations. No previous study has compared CETP and its effect on atherosclerosis between Japanese and US whites. In 2002-2005, random samples of community-based 249 Japanese in Kusatsu city, Shiga and 233 US white men in Alleghency County, Pennsylvania, aged 40 to 49 were examined for coronary artery calcium(CAC) determined by electron-beam computed tomography and serum CETP concentrations. Mean CETP concentration is significantly lower in Japanese than in US(2.24 mg/liter(standard deviation, 0.45) vs. 2.43 mg/liter(standard deviation, 0.49)). Serum CETP was positively associated with CAC in Japanese men after adjusting for other cardiovascular risk factors(Odds ratio(OR) for a 1mg/liter difference in CETP, OR ; 4.27, 95% Confidence interval(CI) : 1.59, 11.5). This relationship was not affected even after adjusting for low density lipoprotein cholesterol and high density lipoprotein cholesterol. Serum CETP was not associated with CAC in US white men(OR, 0.79, 95% CI : 0.40, 1.56). This findings warrant further studies.