Research of incorporation of hepatic perfusion analysis using bigh-spatialresolution MRimaging

在给予5mLGd-螯合物造影剂后，我们进行了肝脏的血流灌注分析。在获得常规动态后。肝脏磁共振成像，单层电影。磁共振成像采用5mLGd对比剂，采用双输入一室模型进行灌注分析。我们得到了肝脏血流量、肝脏血容量、平均通过时间和动脉-门脉分数。我们评估了之前的动态磁共振成像是否不会影响随后的灌注成像的效果。采用双输入一房室模型(MATERNE R，et.艾尔Magn Reson Med 2002；47：135)用于灌注分析。分析得出的几个参数与慢性肝损害或肝硬变的临床分期、肝纤维化的病理分期、Child-Pugh评分和ICG15测试值相关。我们发现，我们的MR灌注分析方法在一定程度上反映了肝纤维化的程度。我们还需要解决一些技术方面的问题，以提高这项技术的准确性。

We performed perfusion analysis of the liver after giving 5-mL gadolinium-chelate contrast material. After obtaining conventional dynamic. MR imaging of the liver, single-level cine. MR imaging was performed with 5-mL gadolinium contrast for perfusion analysis with dual-input-one-compartment model. We obtained hepatic blood flow ; hepatic, blood volume, mean transit time, and arterial-portal fraction. We evaluated if preceding dynamic MR imaging did not hamper the efficacy of subsequent perfusion imaging. We used algorithm of dual-input one-compartment model (Materne R, et. al. Magn Reson Med 2002 ; 47:135) for perfusion analysis. Several parameters derived from the analysis were correlated with clinical stages of chronic liver damage or cirrhosis, pathological stage of hepatic fibrosis, Child-Pugh score, and ICG15 test value. We found that our methodology for MR perfusion nalysis reflected the degree of hepatic fibrosis to a certain extent. We still need to solve some problems in the technical aspects to increase the accuracy of this technique.