Development of closed-loop cardiac-cycle artificial respiration to increase cardiac output

我们研制了一种开环心脏循环人工呼吸。此外，我们进一步开发了一种闭环心脏循环人工呼吸，增加心输出量。我们的系统包括一台个人电脑，从患者周围的可变传感器接收有关呼吸状况的信息，并从位于患者体内的压力和流量传感器接收有关心血管状况的信息。然后，个人计算机控制呼吸机通过DA输出调节气道压力，并在维持呼吸和心血管条件的同时增加心输出量。在正常心脏的狗的动物实验中，我们的系统成功地增加心输出量5- 10%。我们的系统在心脏衰竭的狗身上也很有效。此外，我们的系统减少了维持血液动力学所需的正性肌力药物的量，因为它能够增加心输出量。因此，我们的系统可用于重症监护医学的呼吸和心血管控制。

We developed a open-loop cardiac-cvcle artificial respiration. In addition, we further developed a closed-loop cardiac-cycle artificial respiration that increases cardiac output. Our system consisted of a personal computer that received information about respiratory condition from variable sensors around patients and that about cardiovascular condition from pressure and flow sensors located in patients. The personal computer then controlled ventilator to adjust airway pressure by DA output and to increased cardiac output while maintaining respiratory and cardiovascular conditions. In animal experiments in dog with normal heart, our system succeeded to increased cardiac output by 5-10%. Out system also worked well in dogs with failing heart. In addition, our system decreased the amount of inotropic agents needed to maintain hemodynamics since it was able to increase cardiac output. Accordingly, our system may be useful in respiratory and cardiovascular control of intensive care medicine.