Phospholipid metabolism and lipid mediators
Phospholipid metabolism and lipid mediators
批准号:
19002011
负责人:
SHIMIZU Takao
金额:
$495.79万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Specially Promoted Research
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2011
中文摘要
甘油磷脂是生物膜的主要成分。该研究旨在阐明膜多样性和不对称性的生化机制和结果。我们发现了大约10种不同的溶血磷脂酰基转移酶并对它们进行了表征。我们还开发了用LC-MS分析膜磷脂(超过1500)的新方法。我们现在获得了分子和方法学工具来揭示膜多样性的生物学意义和疾病相关性。
英文摘要
Glycerophospholipids are a major constituent of biological membranes. The study was aimed to elucidate biochemical mechanism and outcome of the membrane diversity and asymmetry. We discovered about 10 different lysophospholipid acyltransferases and characterized them. We also developed new methods to profile membrane phospholipids (over 1,500) by LC-MS. We obtained molecular and methodological tools now to uncover the biological significance and disease relevance of membrane diversity.
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Role of lysophosphatidic acid acyltransferase 3 in sertoli cell function
溶血磷脂酸酰基转移酶 3 在支持细胞功能中的作用
DOI:
--
发表时间:
2010
期刊:
脂質生化学研究
影响因子:
--
作者:
[Andreas Koeberle, Hideo Shindou, Takeshi Harayama, Takao Shimizu]
通讯作者:
Takao Shimizu
Specific ligands as pharmacological chaperons : The transport of misfolded G-protein coupled receptors to the cell surface
特定配体作为药理学伴侣:错误折叠的 G 蛋白偶联受体转运至细胞表面
DOI:
--
发表时间:
2010
期刊:
IUBMB Life
影响因子:
4.6
作者:
[Nakamura, M., Yasuda, D., Hirota, N., Shimizu, T.]
通讯作者:
T.
Alternative arachidonic acid cascade in the brain
大脑中的替代花生四烯酸级联
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[北芳博, 清水孝雄]
通讯作者:
清水孝雄
DOI:
10.1194/jlr.m800500-jlr200
发表时间:
2009-09-01
期刊:
JOURNAL OF LIPID RESEARCH
影响因子:
6.5
作者:
[Harayama, Takeshi, Shindou, Hideo, Shimizu, Takao]
通讯作者:
Shimizu, Takao
リゾホスファチジルコリンアシル転移酵素(LPCAT1)とリゾPAFアセチル転移酵素(LysoPAFAT/LPCAT2)の解析
溶血磷脂酰胆碱酰基转移酶 (LPCAT1) 和 lysoPAF 乙酰转移酶 (LysoPAFAT/LPCAT2) 的分析
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Tsubota, T., et al., 進藤 英雄]
通讯作者:
進藤 英雄
共 99 条
Development of MPB free piezoelectric materials by reversible ferroelastic domain switching
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批准号:19K15288
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项目类别:Grant-in-Aid for Early-Career Scientists
-
资助金额:$2.66万
-
财政年份:2019
-
负责人:SHIMIZU Takao
-
依托单位:
Emergence of giant piezoelectric properties in non-perovskite zirconia-based ferroelectrics
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批准号:25889024
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项目类别:Grant-in-Aid for Research Activity Start-up
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资助金额:$1.75万
-
财政年份:2013
-
负责人:SHIMIZU Takao
-
依托单位:
Anthropological Study of Survival Strategies and Mobility of Qur'anic school and its Taribe in West Africa
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批准号:25770312
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.41万
-
财政年份:2013
-
负责人:SHIMIZU Takao
-
依托单位:
Lipid Mediators and Lipid Metaborome
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批准号:15002004
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项目类别:Grant-in-Aid for Specially Promoted Research
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资助金额:$443.46万
-
财政年份:2003
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负责人:SHIMIZU Takao
-
依托单位:
Roles and regulation of lipid mediators
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批准号:12308034
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$24.87万
-
财政年份:2000
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负责人:SHIMIZU Takao
-
依托单位:
MECHANISM OF NEURONAL DEATH AND REGENERATION
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批准号:10470038
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.54万
-
财政年份:1998
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负责人:SHIMIZU Takao
-
依托单位:
Elucidation of roles of platelet-activating factor receptor by gene targeting.
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批准号:08457033
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.74万
-
财政年份:1996
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负责人:SHIMIZU Takao
-
依托单位:
Pathophysiology and Treatment of Endotoxin Shock
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批准号:07557016
-
项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$8.45万
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财政年份:1995
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负责人:SHIMIZU Takao
-
依托单位:
Molecular mechanism of synaptic plasticity
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批准号:07278103
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$143.42万
-
财政年份:1995
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负责人:SHIMIZU Takao
-
依托单位:
Molecular mechanism of synaptic plasticity
-
批准号:07278101
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$72.9万
-
财政年份:1995
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负责人:SHIMIZU Takao
-
依托单位:
STUDIES ON PHYSIOLOGICAL FUNCTION OF PLATELET-ACTIVATING FACTOR
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批准号:05454165
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项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.8万
-
财政年份:1993
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负责人:SHIMIZU Takao
-
依托单位:
Screening and Development of New Immnomodulatory Drugs using PAF Receptor Gene as a Probe
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批准号:03557017
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
-
资助金额:$10.18万
-
财政年份:1991
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负责人:SHIMIZU Takao
-
依托单位:
Studies on Leukotriene Biosynthesis and Signal Transduction.
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批准号:02454143
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项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$3.78万
-
财政年份:1990
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负责人:SHIMIZU Takao
-
依托单位:
The study on the regulatory mechanism of leukotriene biosynthesis and the metabolic disturbance causing various disorders.
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批准号:62480130
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项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$3.26万
-
财政年份:1987
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负责人:SHIMIZU Takao
-
依托单位:
海外基金