DNA-templated assembly of organic molecule-based magnets

作为一种新的超分子方法来合理化的有机分子基磁体的建设，我们已经提出了“生物启发分子为基础的方法”，其中核碱基之间的互补氢键被引入到稳定的自由基分子与不同的自旋量子数的控制的分子排列。我们已经成功地合成了第一个例子的沃森-克里克型胞嘧啶鸟嘌呤氢键复合物组成的胞嘧啶和鸟嘌呤取代的氮氧自由基分子，其特征在于通过单晶X射线晶体学。作为构建分子自旋组装体的另一种方法，我们提出并设计了以单链寡核苷酸为模板的分子自旋组装体。设计了一个含共价碱基空位的组装体的最小模型系统，在该系统中，碱基取代的自由基应该以碱基特异性的方式被限制。

As a novel supramolecular approach to rationalized construction of organic molecule-based magnets, we have proposed "bio-inspired molecule-based approach", in which the complementary hydrogen bonding between nucleobases are introduced to stable radical molecules with various spin quantum numbers for the control of the molecular arrangement. We have succeeded in synthesizing the first example of a Watson-Crick type cytosine-guanine hydrogen-bonded complex composed of cytosine- and guanine-substituted nitroxide radical molecules, which have been characterized by single-crystal X-ray crystallography. As another approach to construct a molecular spin assembly, we have proposed and designed molecular spin assembly templated by single-stranded oligonucleotides. A minimal model system for the assembly containing a covalent base vacancy has been designed, in which nucleobase-substituted radicals should be confined in the base-specific manner.