The experimental production of the drug delivery system using a bacterial-toxin infection mechanism.

肉毒杆菌毒素复合物具有神经毒素使用凝集素组分转运穿过肠上皮屏障的巧妙机制。因此，对这一机制的阐明有望应用于新型药物传递系统和疫苗的研制。在这项研究中，我们证明了C型HA 3可以与胶原结合。我们还展示了每个HA1突变体的结构和糖结合位点的性质。这些结果产生了新的见解的实验计划，创造新的配合物。

The botulinum toxin complex has the clever mechanism of the neurotoxin transit across the intestinal epithelial barrier using the lectin components. So it seems that the elucidation of this mechanism can be applied to the new drug delivery system and the vaccine development. In this study, we demonstrate that the type C HA3 can bind to the collagen. We also show the architecture and the properties of sugar-binding site of each HA1 mutants. These results yield new insights into the experimental planning of the creation of new complexes.