Development and application of high-throughput screening method for drug-seeds discovery in Chinese traditional medicines

抗体能特异性地识别抗原。分子印迹聚合物是一种合成抗体（人工抗体），也能特异性地识别目标化合物。本研究制备了苦参碱和氧化苦参碱的人工抗体，用于提取中药中苦参碱、氧化苦参碱及其结构相关化合物。此外，制备了姜黄素人工抗体，用于提取中药中的姜黄素及其结构相关化合物。结果表明，这些抗体对中药中目标化合物的特异性提取有很好的效果。

An antibody can specifically recognize an antigen. A molecularly imprinted polymer, which is a synthetic antibody (artificial antibody), can specifically recognize a target compound, too. In this study, artificial antibodies for matrine and oxymatrine have been prepared to extract matrine, oxymatrine and their structurally related compound(s) in Chinese traditional medicines (TCMs). Furthermore, an artificial antibody for curcumine has been prepared to extract curcumine and its structurally related compound(s) in TCMs. The obtained results indicate that these antibodies work very well for specific extraction of the target compounds in TCMs.