Roles of obesity and dietary factors on multistage carcinogenesis and risk assessment

据估计，所有人类癌症中有35%与饮食和肥胖有关。一些报告显示，肥胖和癌症之间存在联系的证据来自于队列研究。为了阐明肥胖和饮食因素在多阶段致癌和风险评估中的作用，我们检测了绿原酸、2-硝基甲苯、邻苯二甲酸酯的DNA损伤和细胞增殖能力，以及高糖和氧化应激状态。这些因素在几种情况下都会导致DNA损伤和基因表达，因此需要进一步的研究来预防由于饮食因素和肥胖引起的癌症。

Estimates suggest that 35% of all human cancers have a linkage to dietary and obesity. Several reports showed the evidences of an association between obesity and cancer derives from cohort studies. To clarify the roles of obesity and dietary factors on multistage carcinogenesis and risk assessment, we examined DNA damage and ability for cell proliferation for chlorogenic acid, 2-nitrotoluene, phthalate and status of high glucose and oxidative stress. These factors could cause DNA damage and gene expression under several conditions, and therefore further studies are needed to prevent cancers due to dietary factors and obesity.