Elucidation of association between retinal ganglion cell death and extracellular matrix in various models of optic nerve degeneration

糖尿病、视神经挤压和青光眼引起的视神经变性的三种模型中，视网膜神经节细胞凋亡的幅度、空间分布和时程存在实质性差异。视网膜神经节细胞、视网膜和视神经胶质细胞水通道蛋白表达的变化在三种模型中有显著性差异。此外，还证实了青光眼视神经变性反映巩膜生物力学的可能性。

There was a substantial difference in magnitude, spatial distribution, and time course of apoptotic death of retinal ganglion cells among three models of optic nerve degeneration induced by diabetes, optic nerve crush, and glaucoma. The changes in aquaporin expression in the retinal ganglion cells and glia in the retina and optic nerve were significantly different among these three models. Besides, the possibility was also demonstrated that the optic nerved degeneration in human glaucoma eyes reflects the scleral biomechanics.