Optimization of bone substitutes in dental field

可吸收或不可吸收的不同形式的各种磷酸钙材料已被用作骨替代物。然而，自体骨移植仍然是骨增量的金标准。尽管目前可用的骨替代物用作骨再生的支架，尽管它们是骨传导的，但它们不刺激骨形成。本项目的目的是开发骨替代物，将其转换为真实的骨，刺激骨形成。首先，我们研制了直径为15μm的羟基磷灰石（HA）纤维材料，并在动物实验中证明该材料可与骨交换而不抑制骨再生。其次，我们将可吸收材料α-TCP与胆固醇合成抑制剂辛伐他汀结合，研制成骨替代材料。我们在动物实验中观察到这种骨替代物刺激骨形成和骨交换。此外，该骨替代物的有效性和安全性在临床研究中得到证实。与临床使用的骨替代物相比，本项目开发的两种骨替代物在牙科领域具有潜在的有效性。

Various calcium phosphate materials of different forms, which are resorbable or not resorbable, have been used as bone substitutes. However, autologous bone graft is still a gold standard for bone augmentation. Although bone substitutes, which are currently available, function as scaffold for bone regeneration and although they are osteo-conductive, they do not stimulate bone formation. The purpose of this project is to develop bone substitutes, which exchange to real bone stimulating bone formation. Firstly, we developed hydroxyapatite (HA) fiber material of 15μm diameter and demonstrated that this material exchanges to bone without inhibiting bone regeneration in animal experiments. Secondary, we developed the bone substitute by combining α-TCP, which is resorbable material, and simvastatin, which is an inhibitor of cholesterol synthesis. We observed that this bone substitute stimulates bone formation and exchanges to bone in animal experiments. Furthermore, efficacy and safety of this bone substitute were confirmed in clinical study. The two bone substitutes, which were developed in this project, would be potentially effective in dental field compared to the ones, which are clinically used.