Community-based molecular preventive study on diabetic nephropathy

模型社区慢性肾脏疾病(CKD)患病率为26.9%，高于日本人平均水平(18.7%)。体重指数与估计的GFR相关，与年龄、性别和血管紧张素转换酶基因多态性无关。β3受体等多态与小而致密的低密度脂蛋白的产生有关，这表明糖尿病肾病的发病率很高。利用家庭和社区支持的饮食降盐计划显著降低了血压和尿白蛋白尿素。提示糖尿病肾病的早期发现和预防具有重要意义。

The prevalence of chronic kidney disease (CKD) was 26.9% in the model community and higher than average (18.7%) for Japanese. The body mass index was associated with estimated GFR independent of age, gender, and ACE polymorphism. Several polymorphisms such as beta3-aderenoceptor were associated with the production of small dense LDL, which shows a high prevalence in diabetic nephropathy. A dietary salt reduction program using family and community support significantly decreased the blood pressure and urine albuminurea. These findings suggest that the early detection and prevention of diabetic nephropathy is important.