Establishment of diagnostic method of causative drug by detection of CD40 ligand expression in acute stage of drug eruption

本研究旨在探讨活化T细胞标志物CD 40配体的表达上调作为药疹患者药疹病原药物的诊断方法。对临床诊断为药疹的患者，检测外周血单个核细胞CD 40配体，并与常规药物试验如斑贴试验、淋巴细胞转化试验、激发试验结果进行比较。在确诊的患者中，约2/3的患者CD 40配体检测阳性，建议临床推广应用。

Upregulation of CD40 ligand, an activated T cell marker, was evaluated to be used as a diagnostic method of causative drug for patients with drug eruption. For patients clinically diagnosed as drug eruption, detection of CD40 ligand on peripheral blood mononuclear was compared with the results of conventional drug tests, such as patch test, lymphocyte transforming test and provocation test. In about two third of patients, whose causative drug was confirmed, CD40 ligand detection test was positive, and this method was suggested to be used clinically.