Development of highly atom-economical synthetic methods based on catalytic cascade reactions

作者研究了基于C-H键活化和多组分反应等原子经济反应的催化级联反应合成方法的发展。因此，发展了几种构建稠合杂环的方法，如吲哚、异喹啉、异吲哚、咔唑和喹唑啉。此外，还实现了麦角生物碱和茉莉碱B的全合成以及三氟甲基烯二肽异构体的高效合成。这些结果为高效的有机合成提供了一个初步的模型。

The author investigated development of synthetic methods based on catalytic cascade of atom-economical reactions such as C-H bond activation and multi-component reactions. Consequently, several methods for construction of fused heterocycles such as indoles, isoquinolines, isoindoles, carbazoles, and quinazolines have been developed. Furthermore, total syntheses of ergot alkaloids and jaspine B, as well as efficient synthesis of trifluoromethylalkene dipeptide isosteres have been achieved. These results provide a preliminary model for efficient organic synthesis.