Mechanisms of the extrapyramidal symptoms caused by methylmercury chloride

有严重水俣病症状的患者，在临床观察到锥体外束征象的情况下，均表现为锥体外束核的病理改变。此外，在全脑严重损伤的情况下，锥体外束核也发生了病理改变。甲基汞处理的小鼠表现出运动亢进。组织病理学检查显示，甲基汞处理小鼠双侧尾状壳核星形胶质细胞增殖的神经元数量明显减少。

The patients who had severe symptom of Minamata disease and, in the case that an extrapyramidal sign was observed clinically, showed pathological changes in the extrapyramidal tract nuclei. In addition, pathological changes were observed in the extrapyramidal tract nuclei in the case that whole brain was damaged severely. The methylmercury treated mice displayed locomotor hyperactivity. Histopathological examination showed significant decrease in the number of neurons with proliferation of astroglias in the bilateral caudate putamen in the methylmercury treated mice.