The control characterization of voice pitch (F0) by auditory feedback and related brain activation of stutters and non-stutterers.

声音的基频（F0）和发音信息通过听觉实时反馈到大脑的语言中枢，以纠正与运动指令的偏差。本研究提出了一种准确描述听觉反馈F0控制特征的方法，并比较了有结巴和无结巴两组的延迟时间约为150ms的脉冲响应峰值幅度。对照组和对照组的反应峰值均依赖于F0，而大多数口吃者的反应峰值不随F0增加而增加。功能性MRI显示右侧颞中回、左右中央前回、左侧额下回和右侧脑岛与F0反馈控制有关。

The information of fundamental frequency (F0) and articulation of voice is fed back in real time by audition to the speech center of the brain for correcting deviation from the motor command. In this study, a method for accurately describing the F0 control characteristics of the auditory feedback was developed, and the peak amplitude of the resulting impulse responses with the latency of approximately 150ms were compared between the groups of people who do and do not stutter. The response peak depended on the F0 for the control subjects of both sexes, while it did not increase with F0 for most of stuttering subjects. Functional MRI revealed the right middle temporal gyrus, right and left precentral gyri, left inferior frontal gyrus and right insula as related to the F0 feedback control.