Novel functions of evolutionarily conserved calpain-7/PalBH in membrane trafficking system.

钙蛋白酶由人类15个基因编码，构成细胞内Ca^2+依赖性蛋白酶家族。它们的功能是保护生物体，因此，钙蛋白酶功能的缺陷会导致死亡或肌肉萎缩症等疾病。在这项研究中，我们专注于calpain-7/PalBH，这是保守的从人类到酵母，但迄今为止还没有得到很好的研究。结果表明，钙蛋白酶-7也像钙蛋白酶-2和-3一样在哺乳动物生命中发挥重要作用。

Calpains, which are encoded by 15 genes in humans, constitute a family of intracellular Ca^<2+>-dependent proteases. They function to protect living organisms, and, therefore, defects in calpain functions result in lethality or diseases like muscular dystrophy. In this study, we focused on calpain-7/PalBH, which is conserved from human to yeast but has not been studied well so far. As a result, it was suggested that calpain-7 also plays essential roles for mammalian life like calpain-2 and-3.