Studies on the role of annexin7 in the pathophysiology and therapies of rheumatoid arthritis using proteomics

类风湿关节炎(RA)是一种慢性炎症性疾病，累及多个关节。除了生物制剂，还应该建立新的治疗方法。我们通过蛋白质组学方法鉴定了一种新的RA相关蛋白--膜联蛋白7，证实了膜联蛋白7的致关节炎作用及其作为转基因小鼠治疗靶点的作用。此外，我们还证明，膜联蛋白7通过IL-8参与了关节炎的发病。我们的研究将有助于建立一种新的RA治疗方法。

Rheumatoid arthritis (RA) is a chronic inflammatory disease, involving multiple joints. In addition to the biologics, novel therapies should be established. We identified a novel RA-related protein of annexin 7 by proteomics, evidenced arthritogenecity of annexin7 and its role as a therapeutic target suing transgenic mice. Further, we evidenced annexin 7 contributed to arthritis through IL-8. Our study would be useful to establish a new therapy for RA.