Preparation of Bioresorbable Nanoporous Fibermats for Bone Regeneration in a Dental Field

以硅氧烷、聚乳酸和碳酸钙为复合材料，制备了具有硅酸盐和钙离子释放能力的新型生物可吸收材料，促进骨形成。它们可以被塑造成100~200μm厚度的非织造纤维垫，由直径~10μm的纳米多孔纤维组成。细胞培养试验表明，这种尺寸设计诱导了骨形成细胞的三维增殖。动物实验证实，该材料具有良好的成骨效果。它们有望应用于牙科领域引导骨再生的膜。

Novel bioresorbable materials with silicate and calcium ions-releasing ability for enhancing bone formation were prepared using composites consisting of siloxane, poly (lactic acid) and calcium carbonate. They could be shaped into nonwoven fibermats of 100～200μm-thickness, consisting of nanoporous fibers of～10μm in diameter. Cell culture tests showed that this dimensional design induced the 3D proliferation of bone-forming cells. The materials were confirmed by animal tests using rabbits to show excellent bone formation. They are expected to be applicable to membranes for guided bone regeneration in a dental field.