Influences of the occlusion on gastroesophageal reflux disease and acid clearance in oral cavity, pharynx and esophagus during sleep

在本研究中，我们假设良好的咬合增加了口腔、咽部和食道的酸清除，从而导致胃食管反流病（GERD）的禁止。(1)骨骼III类错颌合患者的咀嚼功能调查结果表明，GERD症状比正常人更常见。(2)健康成人食道内灌注5 ml酸性溶液（0.1 N HCl）或生理盐水对睡眠磨牙发作的影响研究表明，食道酸化可诱发睡眠磨牙发作。(3)磨牙患者（n=7）胃食管反流发生率高，伴轻度食管炎。这些研究表明良好的咬合与食管酸化、抑制上消化道疾病有关。

In the present study, we hypothesized that good occlusion increases the acid clearance in the oral cavity, pharynx and esophagus, leading to the prohibition of the gastroesophageal reflux disease(GERD).(1) The results of the investigation of masticatory functions in patients with skeletal Class III malocclusion suggested that GERD symptoms were observed more often than in normal subjects.(2) The results of the investigation of the effects of intra-esophageal infusions of 5-mL acidic solution(0.1 N HCl) or saline to the healthy adults suggested that sleep bruxism episodes were induced by esophageal acidification.(3) Bruxism patients(n=7) had high frequency of GERD with a mild esophagitis.These researches show good occlusion has associations with esophageal acidification, suppression of upper gastrointestinal disease.