Mechanisms and roles on phagocytosis of microbes and altered self cells

吞噬清除不需要的细胞是细胞的先天免疫，其分子机制和作用尚不清楚。在本研究中，我们通过Draper发现了细胞内的信号，Draper是我们检测到的一种吞噬细胞受体。我们还在果蝇的凋亡细胞和细菌中发现了Draper配体，提示吞噬细胞受体在先天免疫中起着多配体受体的作用。另一方面，我们确定了影响宿主细胞和体液免疫的细菌因素，并研究了逃避宿主免疫反应的细菌策略。

Elimination of unwanted cells by phagocytosis is the cellular innate immunity, and its molecular mechanism and role have remained to be elucidated. In this study, we found out the intracellular signaling through Draper, a phagocytic receptor we have detected. We also identified Draper ligand in Drosophila apoptotic cells and bacteria, and suggested that the phagocytic receptor in innate immunity acts as a multi ligand-receptor. On the other hand, we identified bacterial factors that influenced with host cellular and humoral immunity, and examined bacterial strategy to escape from the host immune responses.