Analysis of multidrug resistance systems in multidrug resistant bacteria and development of drugs effective on the resistant bacteria

病原微生物引起的传染病是人类死亡的主要原因之一。在发达国家，例如我国和欧洲及北美国家，由多重耐药细菌引起的传染病是严重的问题。临床上使用的许多药物对多重耐药菌无效。本研究的目的是分析多重耐药细菌的多重耐药系统，并开发对此类耐药细菌有效的药物。事实上，我们分析了几种多重耐药细菌的多重耐药系统，并发现了几种对这种多重耐药细菌有效的种子化合物。

The worst 1 of cause of human death is infectious disease by pathogenic microorganisms. In developed countries, such as our country and countries in Europe and North America, infectious diseases by multidrug-resistant bacteria are serious problems. Many drugs used at clinical sites are not effective on the multidrug resistant bacteria. Aims of this research are to analyze multidrug resistant systems in multidrug resistant bacteria and to develop drugs effective on such resistant bacteria. In fact, we analyzed multidrug resistant systems in several multidrug resistant bacteria, and found several seed compounds effective on such multidrug resistant bacteria.