Identification of IL-18-induced Tumor-Cell Migration Inhibitory Factor(s) and Elucidation of its Action Mechanism..

IL-18通过激活T细胞和自然杀伤细胞发挥抗肿瘤作用。我们发现了IL-18的另一个作用，即通过诱导血清中抑制肿瘤细胞移动的因子来抑制肿瘤转移。在本研究中，我们旨在鉴定肿瘤细胞迁移抑制因子(s)。我们发现IL-18不仅在血清中，而且在肝和肺的细胞裂解液中也能诱导该因子，该因子是一种分子量小于30,000道尔顿的蛋白质。我们还发现了几个候选因子。

IL-18 shows an anti-tumor action through activation of T cells and natural killer cells. We found another action of IL-18, i.e., the inhibition of metastasis by inducing the factor(s) in serum which suppresses the tumor cell mobility. In this study, we aimed to identify the tumor-cell migration inhibitory factor(s). We have revealed that IL-18 induces the factor(s) in not only serum but also the cell lysate of the liver and lung and that the factor(s) is a protein of molecular weight of less than 30,000 daltons. We have also found several candidates for the factor(s).