Analysis of iron-acquire receptor protein of Vibrio parahaemolyticus and development of specific growth inhibitor

大多数微生物绝对需要铁来生存和生长。副溶血性弧菌在铁限制条件下产生铁载体，即弧菌铁蛋白（VF）。虽然VF对副溶血性弧菌的生长很重要，但其发病机制仍不清楚。本研究以黑腹果蝇为感染模型，对缺乏VF产生菌的副溶血弧菌缺失突变株进行生长试验。这些结果表明，VF对铁的获取对D.黑腹菌，并影响其致死活性。

Most microorganisms absolutely require iron to survive and grow. Vibrio parahaemolyticus produces siderophore, vibrioferrin(VF), under iron restriction conditions. Although VF is important for growth of V. parahaemolyticus, its role for the pathogenesis remains unknown. In this study, Drosophila melanogaster was used for a growth assay of V. parahaemolyticus deletion mutant which lacks VF producibility, as a infection model. These results indicated that iron acquisition by VF was very important for the growth in D. melanogaster, and affected its lethal activity.