The effects of hepatocyte steatosis and adipocytokines on HCV replication

丙型肝炎病毒（HCV）是一种卫生保健问题，可引起从慢性肝炎到肝硬化和肝细胞癌等一系列肝脏疾病。抗hcv治疗基于一种主要的抗病毒细胞因子干扰素（IFN）。据报道，肥胖是对丙型肝炎治疗反应的独立阴性预测因子。在本研究中，我们研究了游离脂肪酸诱导的肝细胞脂肪变性对HCV复制的影响，以及脂肪细胞因子（脂联素、抵抗素、PAI-1）单独或与IFN联合使用复制子系统对HCV复制的作用。我们的研究结果表明，肝细胞脂肪变性和脂肪细胞因子对HCV复制没有影响。

Hepatitis C virus(HCV) is a health-care problem causing a spectrum of liver disease ranging from chronic hepatitis to liver cirrhosis and hepatocellular carcinoma. Anti-HCV treatments are based on a major antiviral cytokine, interferon(IFN). Obesity is reported to be an independent negative predictor of response to hepatitis C treatment. In the present study, we examined the influence of hepatocyte steatosis induced by free fatty acid on HCV replication and the action of adipocytokine(adiponectin, resistin, PAI-1) alone, or in combination with IFN, on HCV replication using the replicon system. Our results showed that hepatocyte steatosis and adipocytokines had no effect on HCV replication.