Mortality risk from lung cancer among residents living near asbestos product plants

我们调查了居住在石棉制造厂附近而暴露于石棉的个人是否在三个地区经历了石棉相关疾病死亡率的增加。第一项队列研究显示，从1942年到1991年，在每年使用数千吨铁石棉和温石棉的工厂附近居住的502户家庭中，肺癌死亡率显著增加，这表明邻近地区的石棉暴露可能会导致肺癌。第二个队列研究表明，从1914年到2001年，居住在工厂附近的449户家庭的所有暴露组中，与石棉相关的疾病死亡率没有增加，每年使用500吨温石棉。这两项发现的差异可能是由于使用的石棉数量和类型不同造成的。第三个队列研究表明，居住在工厂附近的52户家庭的男性间皮瘤死亡率增加，从1954年到1995年，每年使用3500吨温石棉，从1957年到1975年，每年使用4700吨青石棉。这一发现表明，邻里接触石棉会导致间皮瘤。

We investigated whether individuals exposed to asbestos by living near asbestos-manufacturing plants experienced increased asbestos related disease mortality in three areas. First cohort study showed that lung cancer mortality was significantly increased among the highest exposure group of 502 households living near a plant using annual several thousand tones of amosite and chrysotile from 1942 to 1991, which suggests that neighborhood asbestos exposure can cause lung cancer. Second cohort study showed that asbestos related disease mortalities were not increased among all exposure groups of 449 households living near a plant using annual 500 tones of chrysotile from 1914 to 2001. Difference between the two findings may be caused by difference in amount and type of used asbestos. Third cohort study showed that mesothelioma mortality was increased among men of 52 households living near a plant using annual 3500 tones of chrysotile from 1954 to 1995 and annual 4700 tones of crocidolite from 1957 to 1975. This finding suggests that neighborhood asbestos exposure can cause mesothelioma.