Role of adiponectin in the development of liver cancer

近年来，代谢综合征（metabolic syndrome，MS）是一组常与内脏型肥胖相关的代谢紊乱疾病，被报道可增加肝癌发生的风险。虽然脂联素是一种由脂肪组织分泌的血浆蛋白，具有已知的抗糖尿病和抗动脉粥样硬化特性，但其在肝癌发展中的作用仍不清楚。在我们目前的研究中，我们研究了脂联素敲除（KO）小鼠中移植的肝肿瘤的生长，并证明KO小鼠显示肝肿瘤增殖增加。这些数据表明脂联素在肝癌的发展中可能具有抗肿瘤作用。

Recently, the metabolic syndrome, a cluster of metabolic disorders often associated with visceral obesity, is reported to increase the risk of hepatocarcinogenesis. Although adiponectin is a plasma protein secreted from adipose tissue with known anti-diabetic and anti-atherogenic properties, its role in the development of liver cancer has remained unclear. In our current study, we investigated the growth of the transplanted liver tumors in the adiponectin knock out (KO) mice and demonstrated that KO mice showed the increased proliferation of liver tumors. These data indicated the possible anti-tumor role of adiponcetin in the development of liver cancer.