lnvolvement of non-coding gene U50HG and U50 snoRNA in lymphatic system

为了阐明U 50 snoRNA的未知功能，我们产生了mU 50缺陷型小鼠系。在该小鼠系中，rRNA上的mU 50靶向甲基化与mU 50表达的减少一样减少。mU 50缺陷小鼠在视觉上与野生型同窝小鼠无法区分，但其中一些动物易于淋巴器官缺陷。关于U 50在造血谱系中的强表达，启动子分析揭示了c-MYC和BCL 6参与宿主基因的转录。

To elucidate the not-yet-known function of U50 snoRNA we generated an mU50-deficient mouse line. In this mouse line, mU50-targeted methylations on the rRNA were reduced as with the reduction of mU50 expression. The mU50-deficient mice were indistinguishable from wild-type littermates at sight, but some of those animals were prone to have defects in lymphatic organs. Regarding to the strong U50 expression in hematopoietic lineages, promoter analyses revealed the involvement of c-MYC and BCL6 in the transcription of the host-gene.