Experimental study for the regression of chronic kidney disease and mineral bone disorder(CKD-MBD)

对于慢性肾脏疾病矿物质和骨性疾病（CKD-MBD）的病理表现，直接向甲状旁腺注射活性维生素D或其类似物，并对甲状旁腺肿大和高周转率骨性疾病系统给予维生素D和/或钙化剂可能是有效的。但这些方法难以恢复异位血管钙化。预防炎症过程和弹性蛋白降解可能是重要的。迫切需要进一步的研究来澄清这一点。

To regress the pathological findings resulted from chronic kidney disease mineral and bone disorder (CKD-MBD), it may be effective to directly inject the active vitamin D or its analogue into parathyroid gland and to systemically administrate vitamin D and/or calcimimetics for enlarged parathyroid gland and high turn-over bone disease. But it is difficult to regress ectopic vascular calcification by these methods. It may be important to prevent inflammatory process and elastin degradation for regression. Further studies are urgently required to clarify this point.