Deep brain stimulation and neuronal reorganization

深部脑刺激（DBS）临床效果的机制尚不清楚；然而，DBS可能通过大脑的神经元重组起作用。通过动物模型，我们发现描述因子Pax6在丘脑底核（STN）周围结构中表达，可能成为DBS后神经元再生的有用标志。在患有帕金森病的人类受试者中，STN-DBS的效果与白质体积显著相关，这表明电刺激的有效性可能需要基底神经节-丘脑皮质回路各组成部分之间保持连通性。我们将继续研究建立稳定的STN-DBS动物模型，以检测DBS是否在哺乳动物大脑中实质性地诱导神经元再生。

Mechanisms underlying clinical effect of deep brain stimulation (DBS) are still unclear ; however, DBS may act through neuronal reorganization of the brain. By using animal model, we found that description factor Pax6 is expressed in the surrounding structure of subthalamic nucleus (STN) and may become a useful marker for neuronal regeneration subsequent to DBS. In human subjects with Parkinson's disease, effect of STN-DBS was significantly correlated to white matter volume, suggesting preserved connectivity between components of the basal ganglia-thalamocortical circuit may be required for the effectiveness of electrical stimulation. We continue to study to establish a stable animal model for STN-DBS to detect whether DBS substantially induces neuronal regeneration in the mammalian brain.