The study for the nutritional management of endothelial dysfunction seen in pregnancy-induced hypertension

子痫前期由于内皮功能的激活，导致血管张力和通透性增加。在本研究中，我们研究了口服L-精氨酸加叶酸是否可以改善这种状况并预防先兆子痫的发生。正常孕妇红细胞内L-精氨酸浓度呈上升趋势，而子痫前期患者红细胞内L-精氨酸浓度呈下降趋势。血流介导血管扩张(FMD)，使用超声对血管内皮功能的非侵入性评估在怀孕早期高危妇女减少。从中期开始有争议地服用L-精氨酸1g加叶酸0.8 mg/d，可提高减胎率。综上所述，补充L精氨酸加叶酸可改善高危人群的内皮功能障碍，预防子痫前期的发生。

Preeclampsia causes to increase vascular tone and permeability due to the activation of endothelial function. In the present study, we investigated whether an oral supplementation of L-arginine plus folic acid could improve it and prevent from developing preeclampsia. The concentration of L-arginine in RBC had been increasing in normal pregnant women, while it was reduced in preeclamptic women. Flow mediate vasodilatation (FMD), non-invasive evaluation of endothelial function using ultrasound was reduced in high risk women at early pregnancy. The reduction could be improved by the contentious administration of L-arginine 1g plus folic acid 0.8mg/day from the second trimester. In conclusion, the supplementation of L-arginine plus folic acid might improve the endothelial dysfunction seen in high risk group and prevent onset of preeclampsia.