Efficacy of bone regeneration using PLA and collagen as scaffold around implants

本研究的目的是利用聚乳酸开发牙压下功能性种植支架，我们已经开发了具有动态高强度的可生物降解织物复合材料，人工胶原蛋白和利用间充质干细胞（MSCs）形成骨。首先，我们在体外研究了织物复合材料聚乳酸作为支架的骨形成。其次，我们利用颅骨骨缺损动物模型对支架的成骨能力进行了评估。另一方面，我们评估了人工胶原蛋白支架的骨形成情况。采用骨缺损实验动物模型对各支架的牙周再生能力进行了评价。结果证实了织物复合材料聚乳酸作为支架可以在体外形成骨，即使在动物模型中也可以自行进行骨再生，但视情况而定，并且具有牙周再生能力。结果表明，人工胶原蛋白作为基质干细胞的支架不仅是一种有益的功能材料，而且本身具有骨增强的作用。综上所述，聚乳酸和人工胶原蛋白可以作为支架的有益材料，不仅可以作为支架，本身也可以作为具有骨再生能力的骨替代材料。

The purpose of this research is development of functional dental implantable scaffolds under the occulusal pressure by using of PLA which we have already development of biodegradable fabric composite with dynamically high strength, artificial collagen and also bone formation using mesenchymal stem cells(MSCs). First of all, we investigate bone formation as scaffolds made from fabric composite PLA in vitro. Second, we assessed osteogenic ability as the scaffolds using experimental animal model of bone defects in cranium. On the other hands, we evaluated bone formation as the scaffolds made from artificial collagen. And we assessed periodontal regeneration ability as each scaffolds using experimental animal model of bone defects. As the results, it confirmed that using fabric composite PLA as the scaffolds can be bone formation in vitro, can be bone regeneration itselfs even in the aminal models but depend on circumstance, and can be periodontal regeneration ability. It cleared for the MSCs that artificial collagen using as the scaffolds can be not only beneficial functional materials but also bone augmentations itself. Considering the circumstances results, it suggested that PLA and artificial collagen can perform its beneficial materials as the scaffolds, and can be not only scaffolds but also bone replaceable materials itself which have bone regeneration ability.