Elucidation of relationship between indole produced in periodontopathogenic bacteria and periodontal disease

为了阐明牙龈卟啉单胞菌、具核梭杆菌和中间普雷沃氏菌产生吲哚的分子机制，我们对编码吲哚产生相关酶的tnaA进行了转录分析，并对纯化蛋白进行了酶学表征。阐明了F.吲哚引起的具核质生物膜形成。此外，色氨酸是吲哚生产的底物，也被建议促进微生物的生物膜形成。

To elucidate the molecular mechanism to produce indole in Porphyromonas gingivalis、Fusobacterium nucleatum, and Prevotella intermedia, we carried out the transcriptional analyses of tnaA encoding tryptophanase associated with indole production and enzymatic characterization of the purified protein. We also clarified induction of F. nucleatum biofilm formation by indole. In addition, tryptophan that is a substrate for indole production was also suggested to promote biofilm formation of the microorganism.