Prevention of stomatitis associated with cancer chemotherapy by rinsing and gargling with cevimeline hydeochroride hydrate solution

我们调查了接受癌症化疗的患者对口腔粘膜的直接影响。我们首先研究了口腔炎的特点取决于化疗方案。结果显示，患者首先出现口干，随后出现味觉障碍和口腔炎。然后，我们假设预防口干可以防止这些患者患粘膜炎。盐酸头孢美林水合物（CHH）是一种刺激唾液分泌的药物，可能是预防口腔干燥的理想药物。然后，我们在健康个体中进行了研究，以调查该药剂的效果和毒性特征。在用CHH漱口期间甚至之后唾液量增加，没有明显的毒性。然后，我们进行了一项序贯研究，即接受化疗的患者在第一个周期使用CHH漱口，然后在下一个周期不使用CHH。提示CHH含漱液是预防接受细胞毒化疗药物患者口腔炎的良好选择。

We investigated the influence on oral mucosa directly from the patients who were to receive cancer chemotherapy. We examined first the features of stomatitis depending on the chemotherapy regimen. It showed that the patients experienced dry mouth first followed by taste disturbances and stomatitis. Then, we hypothesized that preventing dry mouth would preclude such patients from getting mucositis. Cevimeline hydeochroride hydrate (CHH) is a drug to stimulate saliva secretion which may be an ideal agent to prevent dryness of the mouth. Then we conducted the study in healthy individuals to investigate the effects and toxicity profiles of this agent. The amount of saliva was increased during and even after gargle with CHH with no discernible toxicity. Then, we performed a sequential study, i.e. the patients who received chemotherapy with CHH gargle for the first cycle and then with no CHH for the next cycle. It is suggested that gargle with CHH is a good candidate to prevent stomatitis in patients receiving cytotoxic chemotherapeutic agents.