Basic study on a new membrane estrogen receptor and search for its selective agonist

在本研究中，我们研究了植物雌激素对培养的牛肾上腺髓细胞儿茶酚胺（CA）动力学的影响。大豆植物雌激素染料木素和烟草主要成分尼古丁刺激了去甲肾上腺素转运体（NET）的功能。柑桔果皮成分褐皮素对乙酰胆碱诱导的CA合成和分泌有抑制作用。本研究结果提示染料木素、尼古丁和诺比列素具有潜在的心血管保护作用。

In the present study, we examined the effects of phytoestrogens on catecholamine (CA) dynamics in cultured bovine adrenal medullary cells. Genistein, a soy phytoestrogen, and nicotine, a major component of tobacco, stimulated the function of norepinephrine transporter (NET). Nobiletin, a component of peel of citrus fruits, suppressed CA synthesis and secretion induced by acetylcholine. The present findings suggest that genistein, nicotine, and nobiletin have a pharmacological potential on cardiovascular protective effects.