Study of neuromuscular interaction

为阐明电刺激大鼠坐骨神经引起肌肉收缩后骨骼肌、运动神经元和神经肌肉接头的适应现象，进行了康复医学的科学研究。通过免疫组织化学观察和分子生物学分析，研究了适应现象的相关因素。结果显示，与肌肉肥大和修复相关的因子和参与神经肌肉接头成熟的因子表达增加，本研究揭示了这些因子的定位和部分信号传递。

This scientific research in rehabilitation medicine was performed in order to clarify the adaptation phenomenon of skeletal muscle, motor neuron and neuromuscular junction followed by muscle contraction induced by electric stimulation of sciatic nerve in rats. Related factors of the adaptation phenomenon were studied by immunohistological observation and molecular biology analysis. As a result, there were increased expression of a factor relevant to muscle hypertrophy and repair and a factor participant in maturity of neuromuscular junction, which location and partial signal transfer were revealed in this study.