Elucidation of functionality of equol-producing bacteria

马雌酚是大豆苷元的代谢物，由肠道内的肠道菌群产生。生活方式预防疾病的雌马酚已被期待。在我们的研究中，通过雌三醇、雌酮和β-雌二醇对产马酚细菌的体外厌氧培养，我们首次发现产马酚细菌能将雌酮强烈转化为β-雌二醇。饲喂0.05%-大豆黄酮-10%猪油日粮的小鼠给予产马酚细菌，影响其脂质代谢和粪便胆汁酸浓度。服用产马酚细菌的小鼠尿液中β-雌二醇的含量明显低于服用生理盐水的小鼠。

Equol is a metabolite of daidzein that is produced by the intestinal flora in the gut. Life style disease prevention of equol has been expected. In our research, In in vitro anaerobic incubation of equol-producing bacteria with estriol, estrone, andβ-estradiol, we firstly elucidated that equol-producing bacteria strongly converted estrone toβ-estradiol. Administration of equol-producing bacteria to mice fed the 0.05%-daidzein-10% lard diet affected the lipid metabolism and fecal bile acid concentration. The urinary amounts ofβ-estradiol were significantly lower in the mice administrated of equol-producing bacteria than in the mice administrated of physiological saline.